Hello I am 38 yr old female and had my total thyroidectomy on January 8th 2009 and was diagnosed with multifocal papillary carcinoma on Jan 26, 2009. Had radioactive iodine treatment in April and have been having difficulty regulating my thyroid since. Had low iodine diet and cytomel prior to treatment to lower thyroid. I am currently on synthyroid 175mcg once a day and cytomel 25 mcg twice a day and my last TSH was 11.4 I am exhausted all the time and my muscles are so fatigued I get cramps all the time in my hips and knees and low back. I just want to feel normal again. Just wondering if anyone else went through the same thing and how long it might take to feel "normal" again. Thanks to anyone with info. Greatly appreciated.